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76 Worcester Business Journal | Book of Lists 2018 | wbjournal.com F O C U S M A N U F A C T U R I N G & T E C H N O L O G Y A fun night, with an important purpose Join honorary co-chairs Massachusetts Senate President Harriette Chandler and Rep. Hannah Kane for a night of camaraderie and solidarity. Every dollar we raise will help Women's Initiative deliver lasting impact to our community, with programs and action to help end violence against young women. Enjoy live entertainment, hors d'oeurvres and a cash bar -- and take part in our silent auction, where you can bid on a wide selection of beautiful designer purses. Tuesday, June 12, 4:30 – 6:30 p.m. ◆ Mercantile Center, 100 Front St., Worcester ◆ Tickets $50 @ www.unitedwaycm.org Thank you to our media partner! Top biomedical companies Ranked by number of local employees Company Local employees Products Head of company Year founded 1 Sanofi Genzyme (a) 15 Pleasant St. Connector, Framingham 01701 508-872-8400 • www.sanofigenzyme.com 1,800 Biotechnology Bill Sibold executive vice president 1981 2 Boston Scientific Corp. 300 Boston Scientific Way, Marlborough 01752 508-683-5670 • www.bostonscientific.com 1,700 Medical devices Michael F. Mahoney president & CEO 1979 3 Waters Corp. 34 Maple St., Milford 01757 508-482-2000 • www.waters.com 1,500 Analytical science technologies Christopher J. O'Connell chairman, president & CEO 1958 4 Quest Diagnostics Inc. 200 Forest St., Marlborough 01752 866-697-8378 • www.questdiagnostics.com 1,450 (b) Diagnostic information services Steve Rusckowski president & CEO 1967 5 Hologic Inc. 250 Campus Drive, Marlborough 01752 508-263-2900 • www.hologic.com 1,245 Medical devices Stephen P. MacMillan president & CEO 1985 6 Integrated Genetics (LabCorp) 3400 Computer Drive, Westborough 01581 508-898-9001 • www.integratedgenetics.com ~1,000 (c) Healthcare diagnostics David P. King president & CEO 1991 7 AbbVie Inc. 100 Research Drive, Worcester 01605 508-849-2500 • www.abbvie.com 900 Biopharmaceutical therapies targeted at immunology, oncology, virology and neuroscience Richard A. Gonzalez chairman & CEO 2013 8 Bristol-Myers Squibb Co. 38 Jackson Road, Devens 01434 978-784-6001 • www.bms.com 715 Diversified specialty biopharmaceuticals for oncology, cardiovascular, immunoscience and fibrosis Giovanni Caforio CEO 1858 9 GE Healthcare Life Sciences (d) 350 Campus Drive, Marlborough 01752 508-475-2000 • www.gelifesciences.com 700 Contrast agents for diagnostic imaging, basic research of cells and proteins and the technologies that enable large-scale manufacturing of vaccines, biologics, cell and gene therapies Emmanuel Ligner president & CEO 2004 9 KARL STORZ Endoscopy-America Inc. (e) 91 Carpenter Hill Road, Charlton 01507 508-248-9011 • www.karlstorz.com 700 Endoscopes, medical instruments and devices Charles Wilhelm president & COO 1989 9 Tegra Medical 9 Forge Parkway, Franklin 02038 508-541-4200 • www.tegramedical.com 700 Precision machining and contract manufacturing for medical device components J. Mark King president & CEO 2007 12 Sunovion Pharmaceuticals Inc. 84 Waterford Drive, Marlborough 01752 508-481-6700 • www.sunovion.com 603 Pharmaceuticals Nobuhiko Tamura chairman & CEO 2010 13 Olympus Surgical Technologies America 136 Turnpike Road, Southborough 01772 508-804-2600 • www.olympus-osta.com 369 Diagnostic and therapeutic endoscopes, advanced energy based hand instruments, sterile single-use devices and implants for urology, gynecology, ear nose & throat and general surgery Joe Doherty president, America Randy Clark group vice president, Medical Systems 2008 14 PerkinElmer Inc. 68 Elm St., Hopkinton 01748 781-663-6900 • www.perkinelmer.com 350 Lab instruments, software, imaging, informatics and services Robert Friel chairman & CEO 1937 15 SMC Ltd. 18 Independence Drive, Devens 01434 978-422-6800 • www.smcltd.com 300 Contract manufacturing for medical and drug delivery devices Brian Payson general manager & VP 1988 16 Nitto Denko Avecia Biotechnology Inc. (f) 125 Fortune Blvd., Milford 01757 508-532-2500 • www.avecia.com 240 Drug development and manufacturing services for oligonucleotide therapeutics Detlef Rethage president 1999 (g) 17 Pall Corp., Biotech Center of Excellence 20 Walkup Drive, Westborough 01581 508-871-5400 • www.pall.com 214 High-tech filtration, separation and purification for life sciences and industry Jennifer Honeycutt president, Pall 1946 18 Johnson Matthey Pharma Services (h) 25 Patton Road, Devens 01434 978-784-5000 • jmfinechemicals.com 200 Active pharmaceutical ingredients from preclinical through commercial production John B. Fowler fine chemicals division director 1972 18 Oxford Immunotec 700 Nickerson Road, Suite 200, Marlborough 01752 508-481-4648 • www.oxfordimmunotec.com 200 Proprietary tests for the management of under- served, immune-regulated conditions Peter Wrighton-Smith CEO 2002 781-652-4500 • www.mustangbio.com 32 SBH Sciences Inc. 4 Strathmore Road, Natick 01760 508-650-6200 • www.SBHSciences.com 18 Recombinant cytokines, cell-based assays and biomarker services Raphael Nir president & CSO 1997 33 Psychemedics Corp. 125 Nagog Park, Acton 01720 978-206-8220 • www.psychemedics.com 12 Manufacturer of drug tests Raymond C. Kubacki chairman, president & CEO 1987 34 NuVascular Technologies Inc. 200 Homer Ave., Ashland 01721 508-881-8860 • www.nuvasculartech.com 10 Artificial blood vessels, heart products, as well as products to treat end-stage renal disease Matthew D. Phaneuf co-founder and chairman 2014 35 Alzheon 111 Speen St., Suite 306, Framingham 01701 508-861-7709 • alzheon.com 9 Therapeutics for Alzheimer's and other neurological disorders Martin Tolar president & CEO 2013 36 Interscope Inc. 100 Grove St., Suite 108, Worcester 01605 877-420-7299 • www.interscopemed.com 8 Novel interventional endoscopic techniques and commercialization of proprietary EndoRotor platform to advance the practice of interventional gastroenterology and pulmonology Jeffery Ryan Jr. co-founder, president & CEO 2011 37 BioSurfaces Inc. 200 Homer Ave., Ashland 01721 508-881-8860 • www.biosurfaces.us 5 Nanotechnology to augment existing medical care and emerging approaches Matthew D. Phaneuf president & CTO 2003 Source: Each company via survey. Note: List includes companies in the biotech, medical device, medical equipment and pharmaceutical industries. Hudson, Wisc.-based Phillips-Medisize acquired Clinton's Injectronics Corp. in June 2016; unable to confirm information about the Clinton facility by press time. Wayland's Candela Corp., a subsidiary of Syneron Inc., was acquired by Apax Partners in April 2017; the company has not responded to the survey since 2015. Biocytogen LLC of Worcester and Ayer's Cambrooke Therapeutics declined to participate in the 2018 survey. Unable to confirm information for Accelovance of Hudson, Marlborough's AngioDynamics, Milford's SeraCare Life Sciences and Holliston's Biostage Inc. (delisted from the NASDAQ in fall 2017) by press time. (a) Sanofi Genzyme is the specialty care global business unit of Sanofi. (b) Includes Worcester's Athena Diagnostics, specialty division of Quest Diagnostics. (c) Local employee figure falls within a range of 1,000-4,999 according to data published by the Executive Office of Labor and Workforce Development. (d) Three facilities, including office and lab space, in Marlborough; one location in Westborough (e) Data from 2017 survey (f) An additional location in Marlborough (g) Founding year for Avecia Biotechnology (h) Data from 2016 survey (i) Fomerly Pexco of Athol; merged with Alpharetta, Ga.-based PPC Industries, owned by Kohlberg & Co. (j) Formerly rEVO Biologics (k) In February 2016, acquired Ocata Therapeutics, which was formerly known as Advanced Cell Technology (l) Founding year for Advanced Cell Technology (m) Affiliate of Hamilton Co. (n) 2018 WBJ Manufacturing Excellence Award winner (o) Succeeded Jonathan Wecker, effective Jan. 1, 2018 (p) Subsidiary of New York-based Fortress Biotech - Compiled by: Stephanie R. Meagher, smeagher@nebusinessmedia.com Source: Each company via survey. Note: List includes companies in the biotech, medical device, medical equipment and pharmaceutical industries. Hudson, Wisc.- based Phillips-Medisize acquired Clinton's Injectronics Corp. in June 2016; unable to confirm information about the Clinton facility by press time. Wayland's Candela Corp., a subsidiary of Syneron Inc., was acquired by Apax Partners in April 2017; the company has not responded to the survey since 2015. Biocytogen LLC of Worcester and Ayer's Cambrooke Therapeutics declined to participate in the 2018 survey. Unable to confirm information for Accelovance of Hudson, Marlborough's AngioDynamics, Milford's SeraCare Life Sciences and Holliston's Biostage Inc. (delisted from the NASDAQ in fall 2017) by press time. (a) Sanofi Genzyme is the specialty care global business unit of Sanofi. (b) Includes Worcester's Athena Diagnostics, specialty division of Quest Diagnostics. (c) Local employee figure falls within a range of 1,000-4,999 according to data published by the Executive Office of Labor and Workforce Development. (d) Three facilities, including office and lab space, in Marlborough; one location in Westborough (e) Data from 2017 survey (f) An additional location in Marlborough (g) Founding year for Avecia Biotechnology (h) Data from 2016 survey (i) Fomerly Pexco of Athol; merged with Alpharetta, Ga.-based PPC Industries, owned by Kohlberg & Co. (j) Formerly rEVO Biologics (k) In February 2016, acquired Ocata Therapeutics, which was formerly known as Advanced Cell Technology (l) Founding year for Advanced Cell Technology (m) Affiliate of Hamilton Co. (n) 2018 WBJ Manufacturing Excellence Award winner (o) Succeeded Jonathan Wecker, effective Jan. 1, 2018 (p) Subsidiary of New York-based Fortress Biotech - Compiled by: Stephanie R. Meagher, smeagher@nebusinessmedia.com Since last year, Marlborough medical device maker Boston Scientific has announced acquisitions that could total more than $1.5 billion. Boston Scientific acquisitions Company acquired Millipede, Inc., Santa Rosa, Calif. $540 million NxThera, Maple Grove, Minn. $406 million Apama Medical, Campbell, Calif. $300 million nVision Medical, San Bruno, Calif. $276 million Securus Medical Group, Cleveland, Ohio $50 million Source: Boston Scientific