Issue link: https://nebusinessmedia.uberflip.com/i/845779
www.HartfordBusiness.com July 10, 2017 • Hartford Business Journal 9 To view the full list, please visit HartfordBusiness.com THE LIST Largest NIH grant winners in Connecticut (FY 2016 grants, ranked by size) Rank Grantee organization Total funding Number of awards Percent of CT awards/ Percent of CT funding Largest project amount Largest project research areas 1 Yale University New Haven $407,245,439 924 78.4% 79.8% $8,409,297 Yale University clinical and translational science award program 2 University of Connecticut School of Medicine/Dental Farmington $49,608,048 115 9.8% 9.7% $2,669,115 Modulation of biodefense responses to microbial pathogens 3 University of Connecticut Storrs $23,231,115 74 6.3% 4.6% $747,055 Multi-sectoral agricultural intervention to improve nutrition, health and developmental outcomes of HIV-infected and affected children in Kenya 4 Haskins Laboratories Inc. New Haven $5,950,077 10 0.9% 1.2% $1,470,442 Nature and acquisition of speech code 5 John B. Pierce Laboratory Inc. New Haven $3,952,772 10 0.9% 0.8% $659,818 Cognitive and affective influences on taste processing 6 Liuna Training and Education Fund Pomfret Center $2,991,754 3 0.3% 0.6% $2,510,288 Hazardous waste worker-training program 7 CT State Dept. of Public Health Rocky Hill, CT $2,837,071 4 0.3% 0.6% $2,738,238 SEER program for assessing the magnitude of the national cancer burden 8 L2 Diagnostics LLC New Haven $2,173,137 4 0.3% 0.4% $879,662 Serologic assay to measure successful Lyme borreliosis antibiotic therapy 9 Hartford Hospital Hartford $1,740,131 4 0.3% 0.3% $722,287 Neural architecture of emotion regulation, adolescent development and depression 10 Connecticut Children's Medical Center Hartford $1,332,762 1 0.1% 0.3% $1,332,762 Predicting response to standardized pediatric colitis therapy 11 Institute for Community Research Hartford $1,053,185 2 0.1% 0.2% $758,051 Examination of multilevel system dynamics affecting HIV community viral load 12 Wesleyan University 45 Wyllys Ave. Middletown, CT 06459 860-685-8000; www.wesleyan.edu $984,499 2 0.1% 0.2% $492,900 Synaptonemal complex proteins in mediation of Class I crossover formation 13 Molecular NeuroImaging LLC New Haven $969,027 1 0.1% 0.2% $969,027 Treatments for mental health 14 Sylvatica Biotech Inc. Stamford $967,103 4 0.3% 0.2% $293,576 Equilibrium sub-cooling for non-frozen banking of human livers 15 Lifefarms Inc. New London $743,940 1 0.1% 0.2% $743,940 Antifungal therapy against drug resistant fungal pathogens 16 Arvinas Inc. New Haven $648,400 1 0.1% 0.1% $648,400 Novel androgen receptor degraders to treat castration-resistant prostate cancer 17 Recombinant Technologies LLC Cheshire $519,209 1 0.1% 0.1% $519,209 Small molecule therapy for Alzheimers disease 18 Next Health LLC Norwalk $511,112 1 0.1% 0.1% $511,112 Development and evaluation of an automated transfer technology 19 Sibtech Inc. Brookfield $456,892 1 0.1% 0.1% $456,892 Clinical development of 18F PET tracer for molecular imaging of vascular endothelial growth factor receptors, the major drug targets in tumor neovasculature 20 Dura LLC Storrs $433,153 3 0.3% 0.1% $199,738 Development of a pediatric transcatheter pulmonary valve system 21 ZetrOZ Inc. Trumbull $400,000 1 0.1% 0.1% $400,000 Self-applied wearable ultrasound therapy for osteoarthritis management in underserved populations 22 Medisynergics LLC Newington $299,998 1 0.1% 0.1% $299,998 Novel trypanocidal compounds for the treatment of stage 1 and 2 HAT 23 CBT4CBT LLC New Haven $293,694 1 0.1% 0.1% $293,694 Method to increase Buprenorphine treatment capacity and effectiveness 24 Oncoarendi Therapeautics LLC Madison $225,000 1 0.1% 0.1% $225,000 Development of an oral acidic mammalian chitinase inhibitor to treat asthma 25 Tangen Biosciences Inc. Branford $216,030 1 0.1% 0.1% $216,030 Rapid detection of multiple drug resistant TB from sputum 26 Protein Sciences Corp. Meriden $168,750 1 0.1% 0.0% $168,750 Vault-CCL21 nanocapsule for lung cancer 27 Ciencia Inc. East Hartford $150,253 1 0.1% 0.0% $150,253 Simultaneous kinetic analyses of neuronal connectivitie 28 Azitra Inc. New Haven $150,000 1 0.1% 0.0% $150,000 Topical application of heterologous protein- expressing staphylococcus epidermidis for potential therapeutic treatment of skin diseases 29 University of Hartford West Hartford $136,859 1 0.1% 0.0% $136,859 Sensory contributions to typical and atypical development of trunk control 30 Connecticut Agricultural Experiment New Haven $108,000 1 0.1% 0.0% $108,000 Role of autophagy in Aedes aegypti vector competence for dengue virus type 2 31 University of Bridgeport Bridgeport $91,271 1 0.1% 0.0% $91,271 Enhancing research administration at an emerging research institution in urban Connecticut 32 Trinity College Hartford, CT $15,000 1 0.1% 0.0% $15,000 Fifth global symposium on ketogenic therapies 33 Cornelia de Lange Syndrome Foundation Avon $6,000 1 0.1% 0.0% $6,000 CdLS scientific symposia, cohesin biology and cohesinopathy meetings Source: National Institutes of Health. Note: The NIH awarded 1,179 grants totaling $510,609,681 to 33 Connecticut organizations in 2016. —Compiled by Stephanie R. Meagher. Largest NIH grant winners in Connecticut (FY 2016 grants, ranked by size) Rank Grantee organization Total funding Number of awards Percent of CT awards/ Percent of CT funding Largest project amount Largest project research areas 1 Yale University New Haven $407,245,439 924 78.4% 79.8% $8,409,297 Yale University clinical and translational science award program 2 University of Connecticut School of Medicine/Dental Farmington $49,608,048 115 9.8% 9.7% $2,669,115 Modulation of biodefense responses to microbial pathogens 3 University of Connecticut Storrs $23,231,115 74 6.3% 4.6% $747,055 Multi-sectoral agricultural intervention to improve nutrition, health and developmental outcomes of HIV-infected and affected children in Kenya 4 Haskins Laboratories Inc. New Haven $5,950,077 10 0.9% 1.2% $1,470,442 Nature and acquisition of speech code 5 John B. Pierce Laboratory Inc. New Haven $3,952,772 10 0.9% 0.8% $659,818 Cognitive and affective influences on taste processing 6 Liuna Training and Education Fund Pomfret Center $2,991,754 3 0.3% 0.6% $2,510,288 Hazardous waste worker-training program 7 CT State Dept. of Public Health Rocky Hill, CT $2,837,071 4 0.3% 0.6% $2,738,238 SEER program for assessing the magnitude of the national cancer burden 8 L2 Diagnostics LLC New Haven $2,173,137 4 0.3% 0.4% $879,662 Serologic assay to measure successful Lyme borreliosis antibiotic therapy 9 Hartford Hospital Hartford $1,740,131 4 0.3% 0.3% $722,287 Neural architecture of emotion regulation, adolescent development and depression 10 Connecticut Children's Medical Center Hartford $1,332,762 1 0.1% 0.3% $1,332,762 Predicting response to standardized pediatric colitis therapy 11 Institute for Community Research Hartford $1,053,185 2 0.1% 0.2% $758,051 Examination of multilevel system dynamics affecting HIV community viral load 12 Wesleyan University 45 Wyllys Ave. Middletown, CT 06459 860-685-8000; www.wesleyan.edu $984,499 2 0.1% 0.2% $492,900 Synaptonemal complex proteins in mediation of Class I crossover formation 13 Molecular NeuroImaging LLC New Haven $969,027 1 0.1% 0.2% $969,027 Treatments for mental health 14 Sylvatica Biotech Inc. Stamford $967,103 4 0.3% 0.2% $293,576 Equilibrium sub-cooling for non-frozen banking of human livers 15 Lifefarms Inc. New London $743,940 1 0.1% 0.2% $743,940 Antifungal therapy against drug resistant fungal pathogens 16 Arvinas Inc. New Haven $648,400 1 0.1% 0.1% $648,400 Novel androgen receptor degraders to treat castration-resistant prostate cancer 17 Recombinant Technologies LLC Cheshire $519,209 1 0.1% 0.1% $519,209 Small molecule therapy for Alzheimers disease 18 Next Health LLC Norwalk $511,112 1 0.1% 0.1% $511,112 Development and evaluation of an automated transfer technology 19 Sibtech Inc. Brookfield $456,892 1 0.1% 0.1% $456,892 Clinical development of 18F PET tracer for molecular imaging of vascular endothelial growth factor receptors, the major drug targets in tumor neovasculature 20 Dura LLC Storrs $433,153 3 0.3% 0.1% $199,738 Development of a pediatric transcatheter pulmonary valve system 21 ZetrOZ Inc. Trumbull $400,000 1 0.1% 0.1% $400,000 Self-applied wearable ultrasound therapy for osteoarthritis management in underserved populations 22 Medisynergics LLC Newington $299,998 1 0.1% 0.1% $299,998 Novel trypanocidal compounds for the treatment of stage 1 and 2 HAT 23 CBT4CBT LLC New Haven $293,694 1 0.1% 0.1% $293,694 Method to increase Buprenorphine treatment capacity and effectiveness 24 Oncoarendi Therapeautics LLC Madison $225,000 1 0.1% 0.1% $225,000 Development of an oral acidic mammalian chitinase inhibitor to treat asthma 25 Tangen Biosciences Inc. Branford $216,030 1 0.1% 0.1% $216,030 Rapid detection of multiple drug resistant TB from sputum 26 Protein Sciences Corp. Meriden $168,750 1 0.1% 0.0% $168,750 Vault-CCL21 nanocapsule for lung cancer 27 Ciencia Inc. East Hartford $150,253 1 0.1% 0.0% $150,253 Simultaneous kinetic analyses of neuronal connectivitie 28 Azitra Inc. New Haven $150,000 1 0.1% 0.0% $150,000 Topical application of heterologous protein- expressing staphylococcus epidermidis for potential therapeutic treatment of skin diseases 29 University of Hartford West Hartford $136,859 1 0.1% 0.0% $136,859 Sensory contributions to typical and atypical development of trunk control 30 Connecticut Agricultural Experiment New Haven $108,000 1 0.1% 0.0% $108,000 Role of autophagy in Aedes aegypti vector competence for dengue virus type 2 31 University of Bridgeport Bridgeport $91,271 1 0.1% 0.0% $91,271 Enhancing research administration at an emerging research institution in urban Connecticut 32 Trinity College Hartford, CT $15,000 1 0.1% 0.0% $15,000 Fifth global symposium on ketogenic therapies 33 Cornelia de Lange Syndrome Foundation Avon $6,000 1 0.1% 0.0% $6,000 CdLS scientific symposia, cohesin biology and cohesinopathy meetings Source: National Institutes of Health. Note: The NIH awarded 1,179 grants totaling $510,609,681 to 33 Connecticut organizations in 2016. —Compiled by Stephanie R. Meagher. It is going to sound cliche, but if you have a great team and keep them focused on the right objectives the CEOs job becomes easier. We had a great team and culture at CyVek; our Chief Technology Officer Marty Putnam and his technical team were just phenomenal. We're in the process of recreating that at Cybrexa. Q: How would you assess the growth of Connecticut's bioscience industry in recent years? I think the growth of startup companies has been strong, and I am encouraged by the state's interest in developing the bioscience industry. The downside is that we are see- ing a lot of the Big Pharma companies either eliminating Connecticut operations or mov- ing to other states. We need to retain the critical mass of talent for the bioscience sec- tor to thrive. I have interviewed a number of scientists recently who lost their big pharma jobs in Connecticut and decided to move to Boston or California where they see better long-term career prospects. n Q&A: Hellsund