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W W W. M A I N E B I Z . B I Z 19 O C T O B E R 1 7 , 2 0 1 6 M I D C O A S T / D OW N E A S T R E G I O N F O C U S Grant money doesn't cover all the funds needed for a research project. "For every $1 of a grant, we add 50 cents to get the work done, which includes overhead such as for animal caretakers. Research is a great loss-leader," Hewett says. Still, technological advances are making research less costly and more efficient. Take the research JAX scientists are doing on Alzheimer's disease, which affects 5.2 million Americans and 40,000 Mainers, according to the Alzheimer's Association. In September, JAX got a $15 million grant over five years from the National Institute of Aging and its partner, the Indiana University School of Medicine, got another $10 million, to create new mouse mod- els that more precisely relate to the pathways and effects of Alzheimer's disease in humans. eir research will build on work by senior research scientist Stephen Murray, who in August was awarded a $28.3 million, five-year grant from the National Institutes of Health for the second stage of a project to research mouse genetic func- tions and their relations to humans. While the first stage of his grant was for $33 million and ended this year, the new grant is for less. at is because he is using a new genetic editing technology called CRISPR/Cas9, which uses a bacterium to precisely cut genes to create new strains of mice that might better approximate disease in humans. e cost to create each new mouse is around $10,000, which is one-tenth to one-third of the money required with conventional techniques. SIZE UP YOUR VALUATION Gain Insight with Valuation and Forensic Experts The issues are complicated. You need an expert who can bring clarity. Leveraging Northern New England's largest accounting and consulting fi rm. Dependable valuations. Defendable results. SHAREHOLDER DISPUTES ECONOMIC DAMAGES LOST PROFITS BUSINESS APPRAISAL BERRYDUNN.COM C O N T I N U E D O N F O L L OW I N G PA G E » Charles Hewett Executive vice president Role: Since 2004 he has overseen the launch of research products and services and the modernization of mouse production facilities. Jennifer Trowbridge Assistant professor Research: Studies adult acute myeloid leukemia and how and why certain cells mutate to cancer. Stephen Murray Senior research scientist Research: With collaborators, is working on the Knockout Mouse Production and Phenotyping Project to determine the function of every mammalian gene. P H O T O S / C O U R T E S Y JA C K S O N L A BO R AT O R Y

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