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16 Worcester Business Journal | April 21, 2025 | wbjournal.com F O C U S HEALTH CARE & LIFE SCIENCES Top NIH grant winners Ranked by number of awards, then total funding in FY 2024 Organization Number of NIH awards Total NIH funding Largest NIH funded project/ largest NIH funded project value 1 UMass Chan Medical School Worcester 372 $200,747,755 Biosafety level 3 laboratory for viral pathogens $7,857,615 2 Worcester Polytechnic Institute Worcester 17 $4,963,722 Charge-based brain modeling engine with boundary element fast multi-pole method $740,004 3 Helixbind Inc. Marlborough 8 $7,979,298 Direct-from-specimen identification of pathogens common in endocarditis $1,001,029 4 Kephera Diagnostics LLC Framingham 8 $5,260,349 Hybrid ELISA: simple and specific one-tier assay for Lyme disease $1,025,000 5 Microbiotix Inc. Worcester 3 $3,072,461 Development of therapeutic products for antibiotic resistant bacteria $2,485,753 6 Altec Inc. Natick 2 $1,261,209 Augmented reality platform for telehealth rehabilitation $700,663 7 Codomax Inc. Worcester 2 $700,000 Optimizing antibody production in CHO cells using Epi-Max technology to increase heavy and light chain expression $350,000 8 Alzheon Inc. Framingham 1 $2,265,244 Randomized, double-blind, placebo-controlled phase 3 study $2,265,244 9 Spatial Surgical LLC Shrewsbury 1 $1,987,032 Computer-guided orthopedic laser $1,987,032 10 Cantata Bio LLC Worcester 1 $1,247,028 Commercialization of rapid, automated Hi-C platform for sensitive genomic profiling of multiple cancer sample types $1,247,028 11 General Biophysics LLC Wayland 1 $1,181,555 Phase 1 trial to assess safety and immune effects of Xenon gas in healthy human subjects $1,181,555 12 Outcome Referrals Inc. Framingham 1 $1,110,421 Placement success predictor: using site-customized machine learning models to predict best level care placement for child's behavioral needs $1,110,421 13 AssayQuant Technologies Inc. Marlborough 1 $1,093,104 Activity-based sensor peptides for direct, high-throughput and kinetic quantitation of oncogenic protein kenases in unfractionated cell and tissue samples $1,093,104 14 AutoIVF Inc. Sudbury 1 $998,710 OvaSafe: microfluidic device enabling automated oocyte vitrification $998,710 15 Pacdna LLC Natick 1 $988,000 Molecular brush-conjugated antisense oligonucleotide as pan-KRAS depletion agent $988,000 16 Biosurfaces Ashland 1 $840,696 Development of cell culture inserts and 3D In Vitro tissue models utilizing novel electrospun scaffolds $840,696 17 Liberating Technologies Inc. Holliston 1 $817,726 Development of bimodal walking-running prosthetic foot $817,726 18 College of the Holy Cross Worcester 1 $361,439 Regulation of inteins: adaptations in extremophiles and targets for drug discovery $361,439 19 Bessor Pharma LLC Framingham 1 $296,931 New target and new therapy for severe Covid-19 and viral hyperinflammation damage; renalase and renalase agonists $296,931 20 Institute For Future Intelligence Inc. Natick 1 $269,691 Adventures in drug discovery: integrating data science into science curriculum $269,691 21 Pioneer Neurotech Inc. Sudbury 1 $214,532 Controlled gradient release of biologics: enhanced nerve conduit for long-gap injury repair $214,532 22 Acpharis Inc. Holliston 1 $202,274 Algorithm and software for predicting structure and degrading efficiency of PROTACs $202,274 23 Luciole Pharmaceuticals Inc. Sherborn 1 $198,117 Discovery and development of OGG1 activators as precision drugs for modification of Alzheimer's disease progression $198,117 24 International Society Of Vaccines Worcester 1 $7,000 2024 annual congress $7,000 Source: National Institutes of Health (NIH) Notes: In fiscal year 2024, NIH awarded 6,021 grants totaling $3.5 billion in funding statewide. Central Massachusetts organizations were awarded 436 grants totaling $241.6 million, which is 7.2% of awards and 6.9% of total funding statewide. The total for Central Mass. includes a $353,102 grant awarded to an unnamed organization in Lunenburg. -Compiled by: Stephanie R. Meagher, research@nebusinessmedia.com Proud supporters of Amy's first steps