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18 Worcester Business Journal | April 17, 2023 | wbjournal.com F O C U S H E A L T H C A R E W E ' V E H E L P E D C L I E N T S S A V E O V E R $ 1 B I N T A X E S T H I S Y E A R . Let Us Help You Save BIG on Taxes! Employee Retention Tax Credits R&D Tax Credits Cost Segregation Business Valuations w w w . J E C - L L C . c o m Top NIH grant winners Ranked by number of awards, then total funding in FY 2022 Organization Number of NIH awards Total NIH funding Largest NIH funded project/ largest NIH funded project value 1 UMass Chan Medical School Worcester 349 $179,947,334 University of Massachusetts Center for Clinical and Translational Science (UMCCTS) $5,145,053 2 Worcester Polytechnic Institute Worcester 15 $4,594,495 MR-guided precision conformal ablation therapy for brain tumors $694,325 3 Helixbind Inc. Boxborough 7 $7,025,221 Direct detection and identification of antimicrobial resistance genes in bloodstream infections $1,050,000 4 Altec Inc. Natick 6 $2,314,214 EMG voice restoration $580,784 5 Microbiotix Inc. Worcester 5 $2,595,825 Screening for rAAV transduction enhancers $986,692 6 Bridge12 Technologies Inc. Framingham 3 $2,883,800 High-power, broadband 395 GHz gyrotron amplifier for DNP-NMR and EPR spectroscopy $1,388,081 7 Alzheon Inc. Framingham 2 $14,500,000 Randomized, double-blind, placebo-controlled, phase 3 study of Alzheimer's disease oral treatment $11,000,000 8 AutoIVF Inc. Sudbury 2 $1,137,848 OvaReady: automated microfluidic oocyte retrieval and denudation device expanding access to IVF $849,973 9 Synspira Therapeutics Inc. Framingham 1 $1,796,643 Novel highly-stable pancreatic enzyme replacement therapy to improve outcomes for patients with pancreatic insufficiency $1,796,643 10 Mustang Bio Inc. Worcester 1 $999,336 Phase 1, open label, multicenter trial to assess safety, tolerability and efficacy of MB-106 in patients with relapsed or refractory CD20+ B-Cell NHL or CLL $999,336 11 Curadel LLC Natick 1 $808,023 ZW800-1: The first zwitterionic NIR fluorophore for cancer imaging and ureter mapping $808,023 12 CG Scientific Inc. Worcester 1 $740,395 Automated system for high-yield pancreatic islet isolation $740,395 13 Bessor Pharma LLC Framingham 1 $672,231 Anti-renalase antibody for tumors resistant to PD-1 inhibitors $672,231 14 Clark University Worcester 1 $450,900 Structure and mechanism of HERC5-dependent ISGylation $450,900 15 Pacdna LLC Natick 1 $400,000 Molecular brush-conjugated antisense oligonucleotide as a pan-KRAS depletion agent $400,000 16 Enrich Therapeutics Inc. Worcester 1 $399,761 Long-term goal to develop fast, hands-free platform that integrates tissue dissociation, clone characterization and isolation to support single celll multiomics $399,761 17 Spatial Surgical LLC Shrewsbury 1 $398,625 Phase 1, integrated cell culture chamber and flow guide for POC, walk-away operation for autologous T-cell manufacturing $398,625 18 Radial Analytics Inc. Acton 1 $350,832 Decision support tool using novel feature extraction and machine learning for early identification of Alzheimer's patients who are candidates for palliative and/or hospice care $350,832 19 General BioPhysics LLC Wayland 1 $313,552 Xenon gas treatment to modulate microglia in neurodegenerative diseases $313,552 20 Acpharis Inc. Holliston 1 $173,006 Deep-learning augmented protein mapping software to screen large compound libraries $173,006 Source: National Institutes of Health (NIH) Notes: In fiscal year 2022, NIH awarded 5,810 grants totaling $3.28 billion in funding to 212 organizations statewide. Central Massachusetts organizations were awarded 401 grants totaling $222.5 million, which is 7% of both awards and total funding statewide. -Compiled by: Stephanie R. Meagher, smeagher@nebusinessmedia.com