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Central MA Life Sciences Report 25 Top NIH grant winners Ranked by number of awards, then total funding in FY 2022 Organization Number of NIH awards Total NIH funding Largest NIH funded project/ largest NIH funded project value 1 UMass Chan Medical School Worcester 349 $179,947,334 University of Massachusetts Center for Clinical and Translational Science (UMCCTS) $5,145,053 2 Worcester Polytechnic Institute Worcester 15 $4,594,495 MR-guided precision conformal ablation therapy for brain tumors $694,325 3 Helixbind Inc. Boxborough 7 $7,025,221 Direct detection and identification of antimicrobial resistance genes in bloodstream infections $1,050,000 4 Altec Inc. Natick 6 $2,314,214 EMG voice restoration $580,784 5 Microbiotix Inc. Worcester 5 $2,595,825 Screening for rAAV transduction enhancers $986,692 6 Bridge12 Technologies Inc. Framingham 3 $2,883,800 High-power, broadband 395 GHz gyrotron amplifier for DNP-NMR and EPR spectroscopy $1,388,081 7 Alzheon Inc. Framingham 2 $14,500,000 Randomized, double-blind, placebo-controlled, phase 3 study of Alzheimer's disease oral treatment $11,000,000 8 AutoIVF Inc. Sudbury 2 $1,137,848 OvaReady: automated microfluidic oocyte retrieval and denudation device expanding access to IVF $849,973 9 Synspira Therapeutics Inc. Framingham 1 $1,796,643 Novel highly-stable pancreatic enzyme replacement therapy to improve outcomes for patients with pancreatic insufficiency $1,796,643 10 Mustang Bio Inc. Worcester 1 $999,336 Phase 1, open label, multicenter trial to assess safety, tolerability and efficacy of MB-106 in patients with relapsed or refractory CD20+ B-Cell NHL or CLL $999,336 11 Curadel LLC Natick 1 $808,023 ZW800-1: The first zwitterionic NIR fluorophore for cancer imaging and ureter mapping $808,023 12 CG Scientific Inc. Worcester 1 $740,395 Automated system for high-yield pancreatic islet isolation $740,395 13 Bessor Pharma LLC Framingham 1 $672,231 Anti-renalase antibody for tumors resistant to PD-1 inhibitors $672,231 14 Clark University Worcester 1 $450,900 Structure and mechanism of HERC5-dependent ISGylation $450,900 15 Pacdna LLC Natick 1 $400,000 Molecular brush-conjugated antisense oligonucleotide as a pan-KRAS depletion agent $400,000 16 Enrich Therapeutics Inc. Worcester 1 $399,761 Long-term goal to develop fast, hands-free platform that integrates tissue dissociation, clone characterization and isolation to support single celll multiomics $399,761 17 Spatial Surgical LLC Shrewsbury 1 $398,625 Phase 1, integrated cell culture chamber and flow guide for POC, walk-away operation for autologous T-cell manufacturing $398,625 18 Radial Analytics Inc. Acton 1 $350,832 Decision support tool using novel feature extraction and machine learning for early identification of Alzheimer's patients who are candidates for palliative and/or hospice care $350,832 19 General BioPhysics LLC Wayland 1 $313,552 Xenon gas treatment to modulate microglia in neurodegenerative diseases $313,552 20 Acpharis Inc. Holliston 1 $173,006 Deep-learning augmented protein mapping software to screen large compound libraries $173,006 Source: National Institutes of Health (NIH) Notes: In fiscal year 2022, NIH awarded 5,810 grants totaling $3.28 billion in funding to 212 organizations statewide. Central Massachusetts organizations were awarded 401 grants totaling $222.5 million, which is 7% of both awards and total funding statewide. -Compiled by: Stephanie R. Meagher, smeagher@nebusinessmedia.com