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wbjournal.com | April 12, 2021 | Worcester Business Journal 25 Top NIH grant winners in Central Mass. Fiscal year 2020 grants, ranked by total funding Grantee Total funding Number of awards Largest project/ funding for largest project 1 University of Massachusetts Medical School Worcester $294,146,927 349 Clinical Studies Core: to fast-track the implementation of selected Center for Advancing Point of Care Technologies (CAPCaT)- supported projects that can help address urgent healthcare issues created by the COVID-19 pandemic $81,242,031 2 Alzheon Inc. Framingham $15,000,000 1 Randomized, double-blind, placebo-controlled, phase 3 study of Alzheimer's disease oral treatment $15,000,000 3 Microbiotix Inc. Worcester $6,132,413 9 Oxadiazole inhibitors of non-stop ribosome rescue to treat MDR Neisseria gonorrhoeae $1,058,081 4 Worcester Polytechnic Institute Worcester $3,884,882 10 MR-guided precision conformal ablation therapy for brain tumors $702,622 5 Helixbind Inc. Marlborough $2,998,005 3 Development of automated IVD for ultra-sensitive, direct, molecular detection of Borrelia for early Lyme disease and culture- free platform for rapid fungal pathogen identification $1,000,000 * 6 Curadel LLC Natick $2,340,855 2 ZW800-1: The first zwitterionic NIR fluorophore for cancer imaging & ureter mapping $1,595,693 7 Bridge12 Technologies Inc. Framingham $1,912,701 4 Compact pulse slicer for high-power submillimeter waves $771,546 8 Kephera Diagnostics LLC Framingham $1,899,827 4 Serologic assays for detection of Zika virus antibodies for clinical diagnosis and blood donor counseling $1,000,000 9 SignaBlok Inc. Worcester $1,706,450 3 First-in-class TREM-1 inhibitors in combination therapy for pancreatic cancer $1,198,246 10 Altec Inc. Natick $1,532,918 3 NeuroMAP system for clinical research $535,902 11 Nirogyone Therapeautics Natick $1,145,470 1 Development of tumor and immuno-metabolism based small molecule therapeutics for refractory breast cancer $1,145,470 12 Bessor Pharma LLC Framingham $1,136,337 1 Renalase: development as an innovative new drug for acute pancreatitis $1,136,337 13 Zata Pharmaceuticals Inc. Worcester $1,010,910 1 Closed system for pathogen reduction of red blood cells for transfusion $1,010,910 14 Clark University Worcester $901,762 2 Investigating molecular mechanisms of transcriptional regulation at Drosophila homeotic genes $450,900 15 Enrich Therapeutics Inc. Worcester $846,875 1 Single clone discovery using an image-based cell isolation platform $846,875 16 Capesym Inc. Natick $834,153 1 Low-cost, low-dose flat panel x-ray detectors with a novel semiconductor $834,153 17 CG Scientific Inc. Worcester $660,379 2 High efficiency microfluidic device for large scale CAR-T cell manufacturing $385,433 18 Liberating Technologies Inc. Holliston $657,815 1 Pointdexter: a prosthetic fingertip terminal device $657,815 19 Biostage Inc. Holliston $498,749 1 Retrievable autologous bioengineered esophageal implant as a novel treatment for long-gap esophageal atresia $498,749 20 MatTek Corp. Ashland $252,129 1 Organotypic culture models (OCM) developed from experimental animals for chemical toxicity screening $252,129 21 Optys Tech Corp. Shrewsbury $252,083 1 SBIR Phase I -cloud-based software for cancer research data commons, period of performance 09/16/2020 to 06/15/2021 $252,083 22 Enable Life Sciences LLC Worcester $224,000 1 Novel serum alternative for ex-vivo expansion of natural killer cells for immunotherapy $224,000 23 Microgradient Fluidics LLC Worcester $168,086 1 Cryo-EM grid preparation using gas dynamic virtual nozzles $168,086 Source: National Institutes of Health, www.nih.gov. Note: The NIH granted 5,654 awards worth $3.3 billion in funding in Massachusetts in FY 2020; 405 awards worth $341.0 million were granted in Central Mass., up from 399 awards and $182.7 million granted in FY2019. * Two projects received $1 million. - Compiled by: Heide Martin, hmartin@nebusinessmedia.com LO KING Many of our doctors are welcoming new patients. Meet them at reliantmedicalgroup.org. for a new doctor? Top NIH grant winners in Central Mass. Fiscal year 2020 grants, ranked by total funding Source: National Institutes of Health, www.nih.gov. Note: The NIH granted 5,654 awards worth $3.3 billion in funding in Massachusetts in FY 2020; 405 awards worth $341.0 million were granted in Central Mass., up from 399 awards and$182.7 million granted in FY2019. * Two projects received $1 million. - Compiled by: Heide Martin, hmartin@nebusinessmedia.com