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12 n e w h a v e n B I Z | M a r c h 2 0 2 1 | n e w h a v e n b i z . c o m Rallybio's co-founders (from left to right) are: Dr. Stephen Uden, Jeffrey Fryer and Martin Mackay. PHOTO | STEVE LASCHEVER Former Alexion execs raise $182M for Rallybio's rare disease treatments search New Haven's Next Big Bioscience Star? By Natalie Missakian J ust 10 months aer Rallybio launched in early 2018, Fierce Biotech, an international trade journal widely followed in the bioscience world, dubbed it one of the year's 15 most promising biotechs. e New Haven-based company had yet to make any groundbreaking discoveries. In fact, it didn't have a single drug in its portfolio. And outside of its announced focus on treatments for severe rare diseases, Rallybio's founders had offered few details about what medical conditions the startup planned to pursue. Still, the company was getting noticed — not only by reporters covering the industry but also by investors — as evidenced by the $37 million it raised shortly aer setting up its first lab and office at UConn's Technology Incubation Program (TIP) in Farmington. Most of the attention was focused on the pedigree of Rallybio's three co-founders — Martin Mackay, Dr. Stephen Uden and Jeffrey Fryer — all former top-level executives at Alexion Pharmaceuticals, whose blockbuster rare blood disorder drug Soliris made it New Haven's biggest biotech success story a decade ago. "It's the dream team," for a rare-disease drug company, said Tim Shannon, a member of Rallybio's board of directors and partner with venture capital firm Canaan Partners, an early Rallybio investor. "It really is a group of world-class people that are fortunately in our midst here in the area. And that holds with the leadership team of Martin, Steve and Jeff — but it goes right through the company." at team has quickly grown to 21 — and all are from Connecticut, as the founders are quick to point out. Many of the initial hires came out of Alexion, but Rallybio has also absorbed scientists from large pharmaceutical companies such as Pfizer and Bristol-Myers Squibb, which, like Alexion, have downsized their Connecticut presence in recent years. Uden, who is Alexion's former head of research, said their ability to assemble such a high-caliber team so quickly speaks to the strength of the state's biotech talent pool. "e problem that drug development innovation faces is not the number of new ideas but the numbers of people who know how to do it," said Uden. "Our secret sauce is really the team that we managed to put together. We would not be the company we are without them." Active year Rallybio is coming off an active year in 2020, when it moved its home office to New Haven's Gold Building at 234 Church St., and began human testing on its first drug, which treats a rare condition causing uncontrolled bleeding in newborns. It also raised another $145 million, bringing its lifetime venture capital fundraising to $182 million. Paul S. Parker, director of the UConn TIP, where Rallybio still maintains an office, told the Hartford Business Journal last year that the company has been one of the most successful fundraisers in the incubator's history. Mackay, Rallybio's CEO and Alexion's former executive vice president and global head of research and development, said the company's genesis was rooted in the founders' desire to continue their life's work helping patients with rare and devastating diseases. e name Rallybio reflects their mission to rally scientists around that goal, he said. Over the last few years, the company has scoured the globe searching for innovative small molecules, antibodies and engineered proteins that it could develop into life- changing treatments. Its first drug came from a startup in Norway, which the founders discovered at a little-known conference in New York that was held by a trade group for biotechs in the Nordic region. "We very quickly realized it was a diamond in the rough that had been passed over," Uden said. e drug is a potential treatment for a life-threatening condition known as Tim Shannon In 2020 Rallybio relocated its headquarters to New Haven's Gold Building at 234 Church St. PHOTO | COSTAR

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