Hartford Business Journal

12 Hartford Business Journal • February 4, 2019 • www.HartfordBusiness.com FOCUS THE LIST Largest NIH grant winners in Connecticut (FY 2018 grants, ranked by total funding) Source: National Institutes of Health. Note: The NIH awarded 1,240 grants totaling $560,899,834 to 35 Connecticut organizations in 2018. —Compiled by Stephanie R. Meagher. Largest NIH grant winners in Connecticut (FY 2018 grants, ranked by total funding) Rank Grantee Total funding Number of awards Percent of CT awards/ Percent of CT funding Largest project amount Largest project research areas 1 Yale University New Haven $454,012,666 971 78.3% 80.9% $9,310,482 Yale University clinical and translational science award program 2 University of Connecticut School of Medicine/Dental Farmington $50,044,105 124 10.0% 8.9% $3,255,415 Inhibition of BACE1 for benefiting Alzheimers patients 3 University of Connecticut Storrs $28,093,333 83 6.7% 5.0% $999,637 Purchase of an Abberior Instruments easy3D STED super resolution microscope for UConn's Advanced Light Microscopy Facility 4 Liuna Training and Education Fund Pomfret Center $3,073,847 2 0.2% 0.5% $2,692,381 Hazardous waste worker-training program 5 John B. Pierce Laboratory Inc. New Haven $2,803,928 5 0.4% 0.5% $824,252 High throughput of protein-based voltage probes 6 CT State Dept. of Public Health Hartford $2,784,591 2 0.2% 0.5% $2,780,671 SEER program for assessing the magnitude of the national cancer burden 7 Haskins Laboratories Inc. New Haven $2,688,851 7 0.6% 0.5% $632,221 Neurochemistry as a moderator of brain networks for reading 8 Hartford Hospital Hartford $1,857,456 4 0.3% 0.3% $775,598 Neural architecture of emotion regulation, adolescent development and depression 9 Dura LLC East Windsor $1,699,983 3 0.2% 0.3% $749,999 Development of a hybrid transcatheter mitral valve replacement and repair device 10 Thetis Pharmaceuticals LLC Branford $1,679,504 3 0.2% 0.3% $1,396,059 Development of TP-317 for the induction and maintenance of remission in ulcerative colitis patients 11 Wesleyan University Middletown $1,545,014 4 0.3% 0.3% $492,496 Synthesis of biologically active molecules with potential to treat fungal and viral infections, and some forms of cancer 12 Oncoarendi Therapeautics LLC Middletown $1,505,420 1 0.1% 0.3% $1,505,420 Development of an oral acidic mammalian chitinase inhibitor to treat asthma 13 L2 Diagnostics LLC New Haven $1,323,657 5 0.4% 0.2% $299,975 Antigen-detection assay to diagnose Babesia microti infection 14 Trinity College Hartford $980,021 3 0.2% 0.2% $580,796 Ketogenic diet and adenosine: epigenetics and antiepileptogenesis 15 Institute for Community Research Hartford $837,134 1 0.1% 0.1% $837,134 Multilevel system dynamics affecting HIV community viral load 16 Prometheus Research LLC New Haven $748,523 1 0.1% 0.1% $748,523 Faster and cheaper delivery of integrated registries 17 CBT4CBT LLC New Haven $693,799 1 0.1% 0.1% $693,799 Method to increase buprenorphine treatment capacity and effectiveness 18 Applikate Technologies LLC Weston $692,728 1 0.1% 0.1% $692,728 Practical high resolution microscopy of un-cut, un- embedded lung biopsies 19 Recombinant Technologies LLC Cheshire $519,209 1 0.1% 0.1% $519,209 Small molecule therapy for Alzheimers disease 20 Southern Connecticut State University New Haven $444,020 2 0.2% 0.1% $394,859 Neurobiological signatures of perception of audiovisual speech in children with autism spectrum disorders 21 Sibtech Inc. Brookfield $299,735 1 0.1% 0.1% $299,735 More accurately identify and monitor patients who are likely to respond to immune checkpoint therapy 22 New England Discovery Partners Branford $295,298 1 0.1% 0.1% $295,298 Targeting STT3A and STT3B to block flavivirus replication 23 Cell Molecular Tissue Engineering LLC Avon $270,000 1 0.1% 0.0% $270,000 Stem cells to enhance and extend continuous glucose monitoring in vivo 24 Mitotherapeutix LLC Cheshire $264,238 1 0.1% 0.0% $264,238 Treatment for acetominophen-induced liver injury 25 Potentiometric Probes LLC Farmington $225,000 1 0.1% 0.0% $225,000 High sensitivity tethered bichromophoric voltage- sensitive dyes 25 Azitra Inc. Farmington $225,000 1 0.1% 0.0% $225,000 Bioengineered skin microbiota for cutaneous mitigation of Netherton syndrome 27 CaroGen Corp. Hamden $224,710 1 0.1% 0.0% $224,710 Immunogenicity of VLV-based vaccines for treatment of chronic HBV 28 ZetrOZ Inc. Trumbull $224,176 1 0.1% 0.0% $224,176 Daily and localized NSAID sonophoresis for symptomatic treatment of knee osteoarthritis 29 Oral Fluid Dynamics Farmington $223,315 1 0.1% 0.0% $223,315 Artificial salivary gland dental implant 30 Results Group Tolland $210,176 1 0.1% 0.0% $210,176 Exoskeleton and exotendon platform for wearable rehabilitation robotics 31 Vascumab LLC Branford $194,928 1 0.1% 0.0% $194,928 Early-stage translational development of product candidates for vascular disorders, thrombotic diseases and pulmonary hypertension 32 University of Bridgeport Bridgeport $89,551 1 0.1% 0.0% $89,551 Building administration and business operations to guide and support research faculty through grant mechanisms 33 Americares Foundation Inc. Stamford $49,900 1 0.1% 0.0% $49,900 Quality of care in free and charitable clinics 34 RxGen New Haven $49,018 1 0.1% 0.0% $49,018 Amyloid beta oligomer induction of Alzheimers disease in nonhuman primates 35 WHM Consulting Lyme $27,000 2 0.2% 0.0% $18,000 Consulting contract Source: National Institutes of Health. Note: The NIH awarded 1,240 grants totaling $560,899,834 to 35 Connecticut organizations in 2018. —Compiled by Stephanie R. Meagher.

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